Used in organic synthesis, intermediates of dyes and medicines, vulcanizing agents, accelerators, and in the manufacture of insulating oil. It can be used to measure the calorific value of fuel, to prepare powder fire extinguishing agent, and as an additive for photodegradable plastics

In the drug database, a substructure search was performed with trifluoromethyl, and a total of 562 drug data were obtained, including 76 listed drugs. Tumors and infectious diseases are still hot areas, and drugs for cardiovascular and cerebrovascular diseases, nervous system diseases, mental disorders, and endocrine and metabolic diseases also account for a considerable proportion. Digestive system diseases, genitourinary system diseases, musculoskeletal and connective tissue diseases, Eye diseases and skin diseases are secondary areas in trifluoromethyl drugs. According to target analysis, cyclooxygenases (COXs), dopamine receptors (DRDs), androgen receptors (AR), epidermal growth factor (EGFR), neurokinin 1 receptor (NK1R), etc. strong representation.